2 edition of Phototransformation of 5-[inferior t]-butyl uracil derivatives found in the catalog.
Phototransformation of 5-[inferior t]-butyl uracil derivatives
Thesis (Ph.D) - University of Birmingham, School of Chemistry, Faculty of Science.
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Fujii S, Kitano S, Ikenaka K, et al: Studies on coadministration of uracil or cytosine on antitumor activity of FT or 5-FU derivatives. Jpn J Cancer Chemother , , Google Scholar: 8. Au JL, Sadee W: Activation of ftorafur (R,S[tetrahydro-2furanyl]fluorouracil) to 5-fluorouracil and gamma-butyrolactone. Rogers, G.T., Ulbricht, T.L.V.: Optical rotatory studies on nucleic acid derivatives, 3-transitions and the relation of the B 2U cotton effect of conformation in pyrimidine and azapyrimidine nucleosides. Europ. J. Biochem. 22, – (), and references cited therein.
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Acyclopseudouridine and acyclopseudoisocytidine and their 1-methyl derivatives were synthesized from 5-(hydroxymethyl)uracil () or by an inferior method from the 5-(chloromethyl)uracil () by reaction with ethylene glycol () (83MI4; 84JHC9).The pyridine analog was similarly prepared from (91T).Methylation of with DMFDMA gave a dimethyl derivatives (R = Me) and.
R.T. Walker, U.L. RajBhandary. coli tyrosine transfer RNA: Chemical modification of thiouridine to uridine. Biochemical and Biophysical Research Communications38 (5), DOI: /X(70) Masao Yano, Hikoya Hayatsu. Permanganate oxidation of 4-thiouracil by: Studies on the chemistry of pyrimidine derivatives with dimethyldioxirane: synthesis, cytotoxic effect and antiviral activity of new 5,6-oxiranyl-5,6-dihydro and 5-hydroxy-5,6-dihydrosubstituted uracil derivatives and pyrimidine nucleosides.
Tetrahedron51 (27), DOI: /(95) by: A new series of uracil analogues-1,2,4-oxadiazole hybrid derivatives were synthesized by a new, simple, and efficient method using for the first time Author: Az-Eddine El Mansouri, Ali Oubella, Mohamed Maatallah, Moulay Youssef AitItto, MohamedZahouily, Hami.
Phototransformation Determines the Fate of 5-Fluorouracil and Cyclophosphamide in Natural Surface Waters. Studies of the electronic structure of 4-N-cytosine derivatives by NMR- NQR double resonance spectroscopy.
Magnetic Resonance in Chemistry37 Interfacial behavior of uracil derivatives. Biophysical Chemistry9 (4), Cited by: After a follow-up of 26, 12, and 17 months, respectively, median survival in months was statistically identical for the first two studies (/, / for raltitrexed and 5-FU, respectively) and inferior for raltitrexed ( vs for 5-FU) in the North American study.
The tolerability profile of raltitrexed on these studies appeared. 1. Introduction. 6-Azauracil (6AU) is an aza-analogue of the nucleobase uracil. It exhibits pronounced biological effect in living organisms.
It inhibits different enzymes in the nucleoside synthesis [, ] and the growth of various types of microorganisms [4,5].The compound is a competitive uracil and uridine antagonist. Each lake water sample was acidified with 2 M HCl (% v/v) and sparged for 10 min with zero-grade air prior to injection and catalytic combustion of organic compounds into CO 2.
Irradiation experiments. Two different series of phototransformation experiments were performed on each filtered lake water sample. Full text of "N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell other formats mm m CHEMISTRY ORIGINAL RESEARCH ARTICLE published: 29 July doi: /fchem.
A/-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture. Uridine consists of uracil, a member of the pyrimidine family of nitrogenous bases, and a ribose.
Of all the characterized and isolated pyrimidine natural products and natural product-derived compounds, uridine is the most abundant. 1 Additionally, uridine appears to be a privileged scaffold for many purposes due to favorable cellular uptake. Specifically, uridine natural products have shown. This has indeed been found, since, 5-FU derived from UFT has a shorter half-life of 40 minutes compared to 2–4 hours for FU derived from S Ethinyl uracil is a more potent inhibitor of DPD leading to an even longer retention of 5-FU, despite the fact that in this formulation, 5.
Oral fluorouracil (5-FU) derivatives used in adjuvant chemotherapy, such as oral uracil and tegafur plus leucovorin (UFT/LV) or capecitabine, were the most commonly used. Results The 3-year relapse-free survival (RFS) rates were % for all cases, % for the surgery alone group, and % for the adjuvant chemotherapy group (P = ).
A novel cyclic-amine monomer, 1-acryloyl-2,2,5,5-tetramethylimidazolidinone (ACTMIO), was synthesized in a good yield through the reaction of acryloyl chloride with 2,2,5,5. E volution of O ral F luoropyrimidines for B reast C ancer C hemotherapy.
More than 50 years have elapsed since 5-FU was developed by Heidelberger et al.  inand during this time, 5-FU has been used as a standard therapy for solid tumors.
5-FU is an analog of uracil with antitumor activity that can be attributed to two main actions .After entering cells, 5-FU is converted to 5. Calculated half-lives under nm wand min for dry nitrogen atmosphere, dry oxygenated atmosphere, and humid oxygenated atmosphere, respectively.
One- and Two-Dimensional EPR Studies on the Radical Pair Generated by the Photoreduction of 9,Anthraquinone-1,5-disulfonate in Aerosol OT Reverse Micelles. The Journal of Physical Chemistry B(9), The potential energy surfaces of stacked uracil dimer (U/U) and stacked thymine dimer (T/T) have been explored at the counterpoise (CP)-corrected MX/+G(d) level of theory, in the gas phase.
the mechanism of photochemical addition of cysteine to uracil and formation of dihydrouracil. Photochemistry and Photobiology11 (5), DOI: /jtbx.
LFP generated transients characteristic of the solvated electron (T = +/- mu s), a microbial-sourced triplet excited state (T = mu s +/- mu s), and a long-lived transient, DOM.
N-alkynyl derivatives of 5-fluorouracil: a clear improvement over derivatives 3c-e but significantly inferior to the reactivity of 3a toward palladium. These results indicate that steric hindrance is a limiting factor in the reaction kinetics and, therefore, suggest that the non-substituted propargyl group is the optimal choice to generate.
The chemotherapeutic compound 5-FU is a uracil analogue with a fluorine atom at the C-5 position. After intravenous administration of 5-FU, it rapidly enters cells using the same transport mechanism as uracil .The processing mechanism of 5-FU in cells is as diverse as that of normal pyrimidines, and the current understanding of the metabolism is summarized in Figure 1.Synthesis of Tricyclo [,5]undecadiones via Intramolecular Photoaddition of 5‐(1‐Cyclopentenylmethyl)‐3‐alkoxy‐2‐cyclopentenones Article Oct Uracil is naturally metabolised by DPD and competes with 5-FU for the enzyme when the two are administered together, resulting in a significantly prolonged half-life for 5 .